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The iPLEDGE program already mandates monthly lab monitoring during isotretinoin therapy, which provides a built-in safety net for catching early glucose or thyroid changes
A 2024 paper in Advances in Nutrition dug into exactly this kind of terminology confusion, arguing that "lean body mass" is a broader category than muscle alone and gets used loosely in ways that blur the distinction
Therefore, gradual dose escalation strategies prove beneficial for enhancing tolerability and treatment adherence
clinical GH-deficiency dosing is individualized to IGF-1
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