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Opiate receptors are coupled with G-protein (guanine-nucleotide-binding protein) receptors and function as modulators, both positive and negative, of synaptic transmission via G-proteins that activate effector proteins
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The starting dose of 0.25 mg equals exactly 10 units, making this the concentration where "10 units" directly corresponds to the standard week-one dose
Xie, H., Tang, S
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