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The wider interactions raise safety issues

Metabolism 99:2531 Herman GA, Stevens C, Van Dyck K, et al (2005) Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: results from two randomized, double-blind, placebo-controlled studies with single oral doses

It turns out it may take longer than that for our colon to adapt to the increased fiber intake

Thyroid, 2020;30(10), 1440-1450.7 Kubiak M, Wiatr K, Kowalczyk A, Grecki R, Gajewska D, Sobieska M

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